Pharmacology of Drug-Tranexamic Acid
	Mechanism of Action		Tranexamic acid exerts antifibrinolytic effect by forming a reversible complex with plasminogen through the lysine binding site of fibrin and thus displaces the plasminogen from the fibrin surface ; preventing the binding of plasmin to fibrinogen or fibrin monomers. It inhibits the activation of plasminogen (i.e. formation of plasmin). It also acts as a weak non competitive inhibitor of plasmin and blocks it`s action on fibrin.
	Pharmaco Kinetics		Absorption: About 40% is absorbed orally. Distribution: Widely distributed in the body. Excretion: Excreted mainly as unchanged drug.
	Half Life		2 hours
	Adverse Effects		1.Nausea  2.Diarrhoea  3.Gastrointestinal problems  4.Headache 5.Hypotension  6.Giddiness  7.Thrombophlebitis at injected vein 8.Impairment of Colour vision
	ContraIndications		1.Thromboembolic disorders  2.Subarachnoid haemorrhage 3.Massive upper urinary tract haemorrhage  4.Colour vision disorders  5.Thrombophlebitis  6.Hepatic impairment  7.Severe renal impairment
	Special Precautions		1.Avoid rapid I.V. administration  2.Lower dosage adjustment is required in renal impairment  3.Monitor liver functioning during long term use
	Pregnancy		Contraindicated
	Breast Feeding		Use with caution
	Old Age		Use with caution
	Indications		1.Surgical procedures  2.Menorrhagia  3. Metrorrhagia  4.Post partum haemorrhage  5.Haemorrhage after abortion 6.Haemorrhage due to contraceptive device insertion  7.Tooth extractions and haemorrhage in other dental procedures 8.Epistaxis  9.Haemoptysis  10.Gastrointestinal bleeding 11.Prostatectomy  12.Tonsillectomy  13.Fibrinolysis  14.Ocular trauma  15.Orthopedic surgery  16.Cardiovascular surgery
	Dosage		Oral: 3 to 4gm/day in 3 to 4 divided doses or 15 to 25mg/kg body wt. 3 to 4 times daily.  I.V.: 1.5 to 3gm/day in 3 divided doses or 10 to 15mg/kg body wt. 3 times daily. Administered as slow I.V. injection or as continuous infusion; at a rate of 25 to 50mg/kg/day.
	Storage		Store below 25 degree C. and protects from light. Keep out of reach of children.
	Over Dose		Treatment is supportive and symptomatic. Remove drug from the body by induced emesis, gastric lavage and administer activated charcoal to reduce absorption. Maintain adequate diuresis with the aid of fluids and diuretics.